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Tiv tauj peb
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Beta-Amyloid (1-42), Tib neeg
Catalog No.: BRS16011
CAS Nr .: 107761-42-2
Cov roj formula: C203H311N55O60S1
Molecular Luj: 4514.1
Purity: Peak Area los ntawm HPLC Ntau dua lossis sib npaug li 95%
Daim ntawv: Lyophilized
Beta-Amyloid (1-42) yog ib qho tseem ceeb molecule nyob rau hauv Alzheimer's kab mob (AD) kev tshawb fawb, paub txog nws siab aggregation propensity thiab neurotoxicity. Nws ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm tsis zoo ntawm lub cev, neuroinflammation, thiab oxidative kev nyuaj siab, ua rau nws lub hom phiaj tseem ceeb rau kev nkag siab AD pathogenesis. Raws li biomarker, txo qis A (1-42) qib thiab A (1-42) / A (1-40) qhov sib piv hauv cerebrospinal kua yog qhov tseem ceeb rau kev kuaj mob. Nws kuj tau siv dav hauv cov qauv neurotoxicity rau kev tshuaj xyuas tshuaj thiab kev tshawb fawb txog kev siv tshuab. Kev siv zog kho mob tsom rau cov tshuaj tiv thaiv kab mob monoclonal (xws li, Aducanumab), kev sib sau ua ke inhibitors, thiab txhim kho cov tswv yim tshem tawm.
Specifications
|
Sequence ib tsab ntawv code |
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
|
Sequence peb tsab ntawv code |
Asp-Ala-Glu-Ph-Arg-Nws{{ 5}}Asp-Ser-Gly-Tyr-Glu-V al-Nws-Nws-Gln-Lys-Leu-Val-Ph-Ph-Ala-Gl u-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Il e-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala |
|
CAS Nr |
107761-42-2 |
|
Molecular Formula |
C203H311N55O60S1 |
|
Molecular Luj |
4514.1 |
|
Kev hloov kho |
N/A |
|
Purity |
Peak Area los ntawm HPLC Ntau dua lossis sib npaug li 95% |
|
Daim ntawv |
Lyophilized |
|
Ntev Cia |
- 20℃lossis qis dua |
| Rau kev tshawb fawb siv nkaus xwb. | |
Cov ntaub ntawv:
1. He, W., Barlogie, B., & Epstein, J. (2004). Amyloid beta protein (1-42) induces neuronal tuag los ntawm p75 neurotrophin receptor.Phau ntawv Journal of Neuroscience, 24(33), 9016–9021.
2. Shankar, GM, Li, S., Mehta, TH, Garcia-Munoz, A., Shepardson, NE, Smith, I., ... Selkoe, DJ (2008). Amyloid-beta protein dimers cais ncaj qha los ntawm Alzheimer's lub hlwb ua rau lub cev tsis muaj zog synaptic thiab nco.Nature Medicine, 14(8), 837–842.
3. Sevigny, J., Chiao, P., Bussière, T., Weinreb, PH, Williams, L., Maier, M., ... Sandrock, A. (2016). Cov tshuaj tiv thaiv aducanumab txo A plaques hauv Alzheimer's kab mob.xwm, 537(7618), 50–56.
4. Fagan, AM, Roe, CM, Xiong, C., Mintun, MA, Morris, JC, & Holtzman, DM (2007). Cerebrospinal kua tau/beta{14}}amyloid(42) piv raws li kev kwv yees ntawm kev paub txog kev poob qis hauv cov neeg laus uas tsis muaj kev xav.Archives ntawm Neurology, 64(3), 343–349.
5. Luo, Q., Lin, Y., & Zhang, Z. (2020). Tus kheej - sib dhos peptide nanomaterials rau kev xa cov amyloid beta inhibitors.Chemical Society Reviews, 49(17), 5619–5637.
Cim npe nrov: Beta-Amyloid (1-42), Tib neeg
Koj Tseem Yuav Zoo Li
