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Xov tooj
+86-0755 2308 4243
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Chaw nyob
Room 309, Meihua Building, Taiwan Industrial Park, No.2132 Songbai Road, Bao'an District, Shenzhen, Suav teb
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Integrin-Targeting Research & cyclo RGD Peptides
Integrins, tshwj xeeb tshaj yog v3 subtype, ua lub luag haujlwm tseem ceeb hauv kev sib kho ntawm tes -extracellular matrix (ECM) kev sib cuam tshuam. Overexpression ntawm cov receptors no yog ib qho cim ntawm cov qog angiogenesis thiab ntau yam qog nqaij hlav, ua rau lawv lub hom phiaj tseem ceeb rau kev xa tshuaj (PDC) thiab cov duab molecular.
Daim duab 1: Molecular kev sib cuam tshuam qauv ntawm Biorunstar's Cyclic RGD (cRGD) peptide khi rau Integrin v 3 qhov chaw ua haujlwm, ua kom pom tias muaj kev txwv li cas (piv txwv li, c(RGDfK)) muab kev txhawb nqa kev sib raug zoo thiab kev ruaj ntseg metabolic rau cov hom phiaj meej.
Biorunstar muab cov ntaub ntawv nthuav dav ntawm siab -purity cyclic RGD (cRGD) peptides tsim los ua kom zoo li lub ntuj khi motif nrog txhim khu kev ruaj ntseg thiab khi affinity. Raws li tus neeg muag khoom cRGD peptide txhim khu kev qha, peb muab siab -cov kev pabcuam zoo cyclic RGD peptide synthesis los txhawb koj cov integrin- tsom rau kev tshawb fawb thiab tshawb nrhiav tshuaj.
Daim duab 2:Biological daim duab qhia txog Integrin v 3 heterodimer activation (los ntawm Bent / Inactive mus rau lub xeev Active), haiv neeg ligand binding (xws li, Fibronectin / Vitronectin), thiab downstream signaling pathways zoo li FAK uas kho cell adhesion, tsiv teb tsaws, thiab ciaj sia taus.
Khoom Series: RGD & Analogs
Peb tshwj xeeb hauv kev sib txuas ntawm cyclic RGD motifs uas muaj cov enzymatic tsis kam thiab siab affinity. Peb cov ntaub ntawv pov thawj muaj xws li kev tswj hwm tshwj xeeb, dimers, thiab kev tsim ua haujlwm rau R & D siab heev.
| Peptide khoom | Sequence / Qauv | Daim Ntawv Thov Kev Tshawb Fawb | |
| c(RGDfK) | Cyclo(Arg-Gly-Asp-D-Ph-Lys) | Kev kuaj mob qog nqaij hlav & qhov chaw-kev sib txuas tshwj xeeb ntawm Lysine sab saw. | |
| c(RGDfC) | Cyclo(Arg-Gly-Asp-D-Phe-Cys) | Precise conjugation ntawm Thiol-Maleimide chemistry rau kub nanoparticles. | |
| c(RADfK) | Cyclo(Arg-Ala-Asp-D-Ph-Lys) | Tsis zoo tswj peptide rau integrin binding thiab cell adhesion assay. | |
| c(RGDyK(Mal)) | Maleimide- ua haujlwm tau zoo | Peptide-Drug Conjugate (PDC) Npaj: Zoo tagnrho rau kev ceev, qhov chaw- tshwj xeeb conjugation rau thiol-muaj tshuaj, proteins, lossis tshuaj tiv thaiv. | |
| c(RGDfV) | Cyclo(Arg-Gly-Asp-D-Ph-Val) | Standard high -affinity antagonist rau v 3 binding inhibition assays. | |
| DOTA-E-[c(RGDfK)]2 | DOTA-conjugated Dimer | Siab -kev sib raug zoo ua ntej rau 68Ga lossis 177Lu radiolabeling hauv kev kho mob qog noj ntshav. | |
| NHS-PEG5K-c(RGDyK)-CY7 | Dual{0}}functional Probe, PEGylated RGD nrog NHS | NIR-Stealth Probe: Sib txuas CY7 fluorescence nrog PEG5K spacer ntev - ncig PK tracing thiab covalent txuas ntawm qhov chaw hloov tau ntev | |
| E[c(RGDyK)2 | Glutamate- txuas Dimer | Dimeric RGD muab kev txhim kho avidity thiab qeeb qeeb dissociation tus nqi. | |
Technical Advantages ntawm Biorunstar cyclo RGD Peptides
Txhawm rau kom ntseeg tau qhov tseeb ntawm koj cov kev soj ntsuam ntawm tes thiab hauv vivo biodistribution kev tshawb fawb, peb cov peptides ua tau raws li cov qauv kev lag luam siab tshaj plaws:
High Purity (>98%):Txhua pawg tau txheeb xyuas los ntawm kev txheeb xyuas HPLC thiab Mass Spectrometry (MS).
Optimized ntsev daim ntawv:Muaj nyob rau hauv Acetate los yog HCl cov ntaub ntawv los txo cov cellular toxicity nyob rau hauv rhiab soj ntsuam.
TFA-Kev xaiv pub dawb:Qhov tseem ceeb rau kev tshawb fawb txog kab lis kev cai ntawm tes kom tsis txhob cuam tshuam nrog kev siv roj ntsha.
Site-Kev hloov kho tshwj xeeb:Cov kws tshaj lij hauv conjugating CY Dyes (CY3, CY5, CY7), NHS esters, Maleimide (Mal), lossis Chelators (DOTA, NOTA) ntawm cov haujlwm meej.
Peev Xwm & Daim Ntawv Thov Scope
Biorunstar's cRGD platform yog tsim los txhawb lub luag haujlwm- kev tshawb fawb tseem ceeb uas Integrin v 3 kev sib raug zoo yog tus thawj coj ua haujlwm:
Molecular Imaging: Optimized rau kev txhim kho siab - sib piv NIR fluorescent probes thiab radiolabeled tracers (PET/SPECT).
Precision Therapeutics: Ua hauj lwm raws li lub hom phiaj moiety rau complex Peptide -Drug Conjugate (PDC) architectures.
Functional Bio-cov ntaub ntawv: High-affinity ligands rau deg functionalization nyob rau hauv cov ntaub so ntswg Engineering thiab cell-adhesion kev tshawb fawb.
Kev Ua Raws & Kev Txiav Txim
Cov Lus Qhia:Tag nrho cov khoom thiab cov kev pab cuam teev nyob rau nplooj ntawv no yog npaj rauLaboratory tshawb fawb thiab kev loj hlob (R&D) lub hom phiaj nkaus xwb. Cov ntaub ntawv no tau muab los ua qib siab - cov tshuaj nruab nrab zoo thiab yogtsis npajrau kev siv tib neeg kev kho mob ncaj qha, kev sim tshuaj kho mob, lossis ua tiav cov tshuaj / tshuaj pleev ib ce.
Quality & Transparency:Txhua peptide yog xa nrog daim ntawv pov thawj ntawm Kev Ntsuam Xyuas (CoA), suav nrog cov ntaub ntawv txheeb xyuas HPLC thiab Mass Spectrometry (MS) kom paub meej txog kev tsim tawm hauv koj qhov kev tshawb fawb.
Tshawb nrhiav peb Cov Kws Tshaj Lij:Peb tsis yog muab peptides xwb; peb daws cov teeb meem nyuaj synthesis.Saib Synthesis Cases
Thov Quote:Rau cov kev cai ua ntu zus, ntau qhov ntsuas - nce, lossis kev sab laj, thov hu rau:Email: sales@biorunstar.com