Cov Khoom Kawg
Tiv tauj peb
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Cyclo(-RGDfK) yog ib qho muaj zog thiab xaiv inhibitor ntawm v3 integrin, nrog IC50 ntawm 0.94 nM[1]. [(66)Ga]DOTA-E-[c(RGDfK)]2 can be prepared with high radiochemical purity (>97%), kev ua haujlwm tshwj xeeb (36-67GBq/μM), nyob rau hauv vitro stability, thiab muaj protein ntau khi. MicroPET imaging mus txog 24 tom qab txhaj tshuaj tau pom qhov sib txawv ntawm cov qog uas cuam tshuam v 3-targeted tracer accumululation[2].
Specifications
|
Sequence ib tsab ntawv code |
cyclo (RGDfK) |
|
Sequence peb tsab ntawv code |
cyclo(-Arg-Gly-Asp-D-Ph-Lys) |
|
CAS Nr |
161552-03-0 |
|
Molecular Formula |
C27H41N9O7 |
|
Molecular Luj |
603.68 |
|
Kev hloov kho |
N/A |
|
Purity |
Peak Area los ntawm HPLC Ntau dua lossis sib npaug li 98% |
|
Daim ntawv |
Lyophilized |
|
Ntev Cia |
- 20℃lossis qis dua |
| Rau kev tshawb fawb siv nkaus xwb. | |
Cov ntaub ntawv:
1. Simecek J, et al. Cov txiaj ntsig ntawm NOPO li chelator hauv gallium-68 peptides, ua piv txwv los ntawm preclinical characterization ntawm (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 Tsib Hlis 5; 11(5): 1687-95.
2. Lopez-Rodriguez V, et al. Kev npaj thiab kev soj ntsuam ua ntej ntawm (66)Ga-DOTA-E(c(RGDfK))2 raws li qhov muaj peev xwm theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14.
Cim npe nrov: cyclo (RGDfK)
Cov ntaub ntawv
COA. ua pdf
HPLC. ua pdf
MS. ua pdf
Citations
Yam khoom
Koj Tseem Yuav Zoo Li
