Peptide Radioligands

Peptide Radioligands

Chelators zoo li DTPA, DOTA, DOPA, NOTA, NODAGA, thiab HYNIC feem ntau txuas rau N-terminus ntawm peptides, tab sis kuj tuaj yeem txuas rau sab hauv lossis C-terminus ntawm ib qho lysine ntxig. Cov chelator no-peptide complexes tsim cov koom haum ruaj khov nrog cov hlau ions, ua kom yooj yim rau lawv txuas rau kev siv tshuaj kho mob lossis kev kuaj mob.

DTPA

Diethylenetriaminepentaacetic acid (DTPA) yog ib qho tseem ceeb chelating tus neeg sawv cev rau radionuclides xws li (68) Ga, (99m) Tc thiab (111)In, uas muaj feem xyuam rau cov tshuaj nuclear.

DOTA

Hlau complexes ntawm DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-peptide conjugates tau nce siv los ua cov phiaj xwm duab thiab kho cov tshuaj radiopharmaceuticals thiab MRI sib piv.

Lwm yam Radioligands