Methylated Peptide

 

Methylated peptides yog ib hom kev tshaj tawm ntawm kev hloov pauv hloov pauv (PTMs), suav nrog lysine, arginine, thiab cysteine ​​methylation. Biorunstar muaj kev paub dhau los hauv kev sib txuas ntawm cov ntawv hauv qab no - hloov pauv peptides:

Arginine methylation Peptide Hloov kho

Arginine methylated tau koom nrog ntau yam txheej txheem ntawm tes, suav nrogKev tswj hwm kev hloov pauv, RNA metabolism thiab kho DNA puas. Lawv cov qauv tsim muaj raws li hauv qab no:

 

Lysine Methylation Peptide Hloov Kho

Lysine methylation yog txwv rau ib pawg ntawm cov proteins thiab catalysed los ntawm cov methyltransferases tshwj xeeb uas tuaj yeem tsim mono-, di-, thiab trimethylated lysines. Cov kev hloov pauv no ua rau muaj kev hloov pauv hauv cov protein: kev sib cuam tshuam ntawm cov protein, cov qauv chromatin thiab cov noob qhia. Lawv cov qauv tsim muaj raws li hauv qab no:

Glycosylation yog ib qho ntawm cov tshaj tawm tshaj plaws - kev hloov pauv hloov pauv ntawm cov protein, nrog rau cov txiaj ntsig tseem ceeb ntawm cov protein folding, conformation, tis, stability thiab kev ua si.

 

N- txuas glycosylation

N-linked glycosylation yog covalently txuas rau cov protein ntawm asparagine (Asn) residues los ntawm N-glycosidic, thiab tseem ceeb rau ob qho tib si cov qauv thiab kev ua haujlwm ntawm qee cov protein eukaryotic.

 

O- txuas glycosylation

O-Txuas glycosylation yog tsim los ntawm kev sib txuas ntawm cov amino acid hydroxyl sab saw (feem ntau yog los ntawm serine lossis threonine) nrog cov glycan. Feem ntau ntawm O- txuas glycans siv daim ntawv GlcNac- -Ser/Thr lossis GalNac- -Ser/Thr.

 

Lwm yam PTMs

Myristoylation, Palmitoylation, Pyroglutamate (Pyr), Proline hydroxylation (Hyp).