PACAP-38 (tib neeg, Nas, Ovine, Porcine, Rat)

PACAP-38 (Pituitary Adenylate Cyclase-Activating Polypeptide-38) yog ib qho neuropeptide muaj li ntawm 38 amino acids, tau txais kev cawmdim thoob plaws ntau hom, suav nrog tib neeg, nas, yaj, npua, thiab nas. Nws plays ntau yam physiological luag hauj lwm nyob rau hauv ntau yam systems. PACAP-38 txhawb nqa kev muaj sia nyob ntawm lub paj hlwb los ntawm txoj kev cAMP-PKA, txo cov kev ntxhov siab oxidative thiab o. Nws kuj tswj cov kev ua haujlwm ntawm T hlwb thiab macrophages, inhibiting qhov tso tawm ntawm inflammatory cytokines, yog li pab txhawb kev tiv thaiv kab mob. Hauv cov hlab plawv, PACAP-38 txhim kho myocardial muaj nuj nqi thiab inhibits cardiomyocyte apoptosis los ntawm kev ua kom txoj hauv kev adenylyl cyclase. Tsis tas li ntawd, nyob rau hauv lub plab zom mov, nws modulates cov leeg nqaij contraction thiab secretion los ntawm enteric paj hlwb.

Specifications

Cov ntaub ntawv:

1. Vaudry et al.,"Pituitary adenylate cyclase-activating polypeptide thiab nws cov receptors: 20 xyoo tom qab kev tshawb pom," Pharmacological Xyuas, 2009.

2. Abad et al.,"PACAP modulates lub cev tiv thaiv kab mob hauv lub cev rau cov kab mob endotoxins," Phau ntawv Journal of Neuroimmunology, 2006.

3. Szakaly et al.,"PACAP hauv cardioprotection," Phau ntawv Journal of Molecular Neuroscience, 2012.

4. Sundler et al.,"PACAP thiab kev hnov ​​​​mob neurons hauv plab," Annals ntawm New York Academy of Sciences, 1996.

5. Cline et al.,"PACAP signaling thiab nws lub luag haujlwm hauv kev mob qog noj ntshav," Endocrine-Related Cancer, 2009.

Cim npe nrov: pacap-38 (tib neeg, nas, ovine, porcine, nas), pacap-38 (tib neeg, nas, ovine, porcine, nas)