1, Kev kho mob teb
(1) Kev kho mob metabolic
Ntawm cov npe tshuaj polypeptide, peb thaj chaw saum toj kawg nkaus suav nrog ntshav qab zib. Hauv xyoo 2022, cov tshuaj insulin cuav thiab cov tshuaj uas tsis yog insulin hypoglycemic yog kaum cov tshuaj polypeptide saum toj kawg nkaus hauv kev muag khoom thoob ntiaj teb, thiab yim yam tshuaj yog ntshav qab zib lossis tshuaj rog rog. Piv txwv li, smeglutide qhov muag ntim yuav ncav cuag 10.914 billion las hauv 2022. Lub ntiaj teb kev lag luam loj ntawm cov tshuaj insulin ntsig txog peptide mus txog $ 27.2 nphom hauv 2020 thiab xav tias yuav loj hlob mus txog $ 40.2 billion los ntawm 2030; Kev lag luam tsis yog insulin xav tias yuav loj hlob los ntawm 35.7 billion US las hauv 2020 txog 101.7 billion US las hauv 2030, qhia tias peptide raw cov ntaub ntawv muaj ntau yam kev siv thiab kev lag luam loj loj hauv kev kho cov kab mob metabolic.
(2) Kev kho mob qog nqaij hlav
Peptides tau nyiam ntau yam hauv kev kuaj mob qog noj ntshav thiab kev kho mob. Vim lawv qhov me me, kev sib raug zoo siab, kev hloov kho yooj yim, thiab kev tiv thaiv kab mob tsawg, cov qog nqaij hlav peptides muaj cov qog / cov nqaij permeability ntau dua piv rau cov tshuaj tiv thaiv kab mob, thiab tuaj yeem siv rau kev tshuaj ntsuam xyuas, kuaj mob qog noj ntshav, thiab cov tshuaj xa mus. Cov tshuaj Peptide conjugated (PDCs) yuav tsum dhau los ua cov tiam tom ntej ntawm cov tshuaj tiv thaiv qog noj ntshav, tom qab cov tshuaj me me, cov tshuaj tiv thaiv monoclonal, thiab ADCs. Tam sim no, mifepristone thiab carfilzomib tau pom zoo rau kev kho mob osteosarcoma thiab ntau yam myeloma, raws li. Ob hom PDCs (Melflufen thiab Lu dotatate) tau txais kev pom zoo los ntawm FDA, nrog Melflufen ua ke nrog dexamethasone tau pom zoo rau kev kho mob ntawm cov neeg mob rov qab los yog refractory ntau myeloma (R / RMM) (txawm hais tias tshem tawm vim muaj kev txhawj xeeb txog kev nyab xeeb). 177Lu dotatate tau txais kev pom zoo rau kev kho mob ntawm plab hnyuv kab mob pancreatic neuroendocrine hlav (GEP-NETs) hauv 2018. Ntawm cov tshuaj peptide muag muag, cov qog nqaij hlav suav txog 30%, qhia nws qhov tseem ceeb hauv kev kho mob qog noj ntshav.
(3) Kev kho mob rau lwm yam kab mob
Cov tshuaj peptide yog tsim rau ntau yam kab mob, nrog rau cov kab mob plawv thiab cerebrovascular, kab mob sib kis, kab mob tiv thaiv kab mob, kab mob plab (kwv yees li 14% ntawm cov tshuaj peptide muag), kab mob orthopedic, kab mob obstetric, thiab lwm yam. Lawv kuj tuaj yeem siv rau cov tsis tshua muaj. kab mob uas tsis muaj txoj kev kho mob. Nws kuj tseem tuaj yeem siv rau kev kho mob ntev xws li cov kab mob musculoskeletal, qhia tias peptide raw cov ntaub ntawv tau koom nrog ntau yam kev kho mob.
2, Cov chaw nqa tshuaj
Peptides, raws li cov neeg nqa tshuaj, tuaj yeem tsis tsuas yog hloov kho rau cov neeg nqa tshuaj, tab sis kuj yog cov khoom tseem ceeb ntawm cov neeg nqa tshuaj. Piv txwv li, Law et al. tsim peptide ntu txuas nrog rau qhov chaw protease cleavage. Tom qab sib sau ua ke nyob rau hauv ib tug haum hnyav, cov tshuaj yog encapsulated nyob rau hauv microspheres. Thaum nws ntsib lub hom phiaj protease, qhov chaw cleavage yog cleaved, ua tiav lub hom phiaj tso tawm ntawm cov tshuaj. Peng Shiqi et al. siv arginine glycine aspartic acid serine serine (RGDS) tetrapeptide hloov liposomes ua cov neeg nqa tshuaj rau kev qhia thrombolysis. Cov cab kuj thiab cov tshuaj txuas nrog rau hauv daim ntawv ntawm cov kua qaub rhiab heev covalent daim ntawv cog lus, uas tuaj yeem biodegraded mus rau hauv cov khoom endogenous Glu nyob rau hauv cov xwm los yog nyob rau hauv tib neeg lub cev, thiab tsis nquag mus tsub zuj zuj thiab tshuaj lom phiv.
3, Khoom noj khoom haus teb
Raws li hom tshiab ntawm cov zaub mov noj qab haus huv lossis cov khoom noj ntxiv, cov khoom noj peptide muaj cov yam ntxwv tshwj xeeb thiab kev ua haujlwm, thiab muaj ntau yam zoo hauv kev noj haus. Lawv muaj cov ntawv thov dav dav hauv kev lag luam khoom noj khoom haus, uas qhia ncaj qha tias peptide raw cov ntaub ntawv muaj peev xwm siv tus nqi hauv cov khoom noj khoom haus.
4, Cosmetics teb
Peptides nrog cov lej sib txawv ntawm cov amino acid residues muaj qhov sib txawv hauv cov tshuaj pleev ib ce. Piv txwv li, tripeptides yog ib qho tseem ceeb ntawm kev loj hlob, tetrapeptides muaj cov tshuaj tiv thaiv kab mob, pentapeptides tuaj yeem txhawb collagen thiab ua kom cov tawv nqaij tuab, hexapeptides yog hom botulinum toxin uas tuaj yeem so wrinkles, thiab nonapeptides tuaj yeem thaiv melanin thiab muaj cov nyhuv whitening. Tam sim no, peptides siv nyob rau hauv cov tshuaj pleev ib ce feem ntau yog peptides nrog txog rau rau cov amino acid residues, yog li peptide raw cov ntaub ntawv kuj muaj daim ntawv thov nyob rau hauv cov tshuaj pleev ib ce teb.