Kev hloov pauv Peptide yog hais txog cov txheej txheem ntawm tshuaj lom neeg lossis kev kho mob biochemical ntawm peptides txhawm rau txhim kho lawv cov khoom lossis tso cai rau lawv nrog cov haujlwm tshwj xeeb. Muaj ntau txoj hauv kev hloov pauv peptide, suav nrog tab sis tsis txwv rau cyclization, N-methylation, phosphorylation, cardamoylation thiab palmitoylation, glycosylation, thiab lwm yam. Hauv qab no yog cov lus qhia luv luv rau ntau hom kev hloov pauv peptide thiab lawv lub hom phiaj:
Kev tiv thaiv ib puag ncig:
Los ntawm kev sib txuas ntawm qhov sib txawv ntawm cov saw peptide los tsim cov qauv cyclic, kev ruaj ntseg thiab kev lom zem ntawm peptide tuaj yeem txhim kho.
Raws li cov kev sib txuas sib txawv, cyclization tuaj yeem muab faib ua cov saw hlau sab saw cyclization, davhlau ya nyob twg sab saw cyclization, thiab davhlau ya nyob twg davhlau ya nyob twg cyclization.
N-methylation:
N-methylation ua rau peptides resistant rau biodegradation los ntawm kev tiv thaiv kev tsim ntawm hydrogen bonds.
Peptides tuaj yeem tsim los ntawm kev siv N-methylated amino acid derivatives, lossis los ntawm kev hloov kho tom qab siv cov tshuaj tiv thaiv tshwj xeeb xws li cov tshuaj tiv thaiv Mitsunobu.
Phosphorylation:
Phosphorylation yog ib qho kev hloov pauv tom qab kev txhais lus, tshwj xeeb yog qhov tseem ceeb rau kev tswj cov txheej txheem ntawm tes.
Cov hom phiaj phosphorylation yog serine, threonine, thiab tyrosine residues.
Qhov no tuaj yeem ua tiav los ntawm kev xaiv tshem tawm cov pab pawg tiv thaiv lossis siv cov tshuaj phosphorylating tshwj xeeb.
Cardamom acylation thiab palmitoylation:
Los ntawm kev ntxiv cov roj fatty acids ntawm N-terminus ntawm peptides, kev khi ntawm peptides thiab cell membranes tau nce.
Acylation ntawm cardamom pab txhawb lub zos ntawm qee cov protein kinases thiab thim rov qab transcriptase rau cov cell membrane.
Glycosylation:
Glycosylation tsis tsuas yog nce qhov nyuaj ntawm peptides, tab sis kuj tseem ua lub luag haujlwm txhawb kev tiv thaiv kab mob thiab kho kab mob.
Piv txwv li, glycopeptide tshuaj tua kab mob xws li vancomycin txhim kho lawv cov tshuaj tua kab mob los ntawm glycosylation.
Cov ntsiab lus saum toj no yog raws li cov ntaub ntawv tsis ntev los no thiab qhia txog cov ntsiab lus ntawm kev hloov pauv peptide thiab lawv qhov tseem ceeb hauv biology thiab tshuaj. Txhua qhov kev hloov kho muaj nws cov xwm txheej tshwj xeeb thiab cov teebmeem, thiab xaiv cov kev hloov kho uas tsim nyog yog qhov tseem ceeb rau kev tsim cov tshuaj tshiab thiab cov khoom siv roj ntsha.