Disulfide - Txoj cai sib khi ntawm peptides thiab ick cov qauv

Kev Taw Qhia Cov Ntsiab Lus

Disulfide Land Cyclization ntawm Csteines Txuas Ob Ntu Cov Cys nyob ntawm S-S CERO CIM. Cov neeg nqus tau cov cystine (ick) peptides yog ib chav kawm ntawm xws ceplic peplic ua tus cwj pwm los ntawm peb qhov kev ntxub ntxaug "cystine pob caus". Tshwj xeeb, ob qho kev tsis txaus siab (thiab cov ntu rov qab cuam tshuam) tsim lub nplhaib, thiab cov xov disulfide ntawm lub nplhaib no los tsim cov sab topology. Lub tsev neeg Ock suav nrog ntau peptides thiab lawv cov homologes cyclized (cycloterides), uas ua rau scaffolds vitractivities thiab pab ua qauv tsim qauv tshuaj lossis biopestricicides.

Kev tsis ncaj ncees tshuab

Tus schematic sab saud ua piv txwv ntawm cov qauv cyclotrotide (Kalata B1) nrog peb daim ntawv uas muaj kev puas tsuaj (daj) tsim lub kaus mom cystine. Qhov interlocked Toplicate tsim lub zog kom nruj {2} Pepted Hydrophobic tub ntxhais, rendering ick peptides expective expective expradation. Piv txwv li, tus kab laug sab {{4 4}} Venom Toxin HV1A (nyob rau qib ick, ntawm pH 1, thiab nyob rau hauv muaj kev tiv thaiv zoo; Nws cov poob qis qis ntxiv thaum tsis muaj kev cuam tshuam tau txo. Hauv lwm lo lus, lub kab ntxwv qhib ua kom muaj cov cua sov, tshuaj, thiab proteolytic ruaj khov ntawm cov peptides no.

Cov Ntawv Thov

Oick Peptides muaj cov kev siv muaj txiaj ntsig hauv kev kho thiab ua liaj ua teb. Ntau cov luas -} peptides: kev coj noj coj ua hauv qhov ncauj, VGLYCIN) ua yeeb yam zoo li cas los xij piam thaj. Hauv kev ua liaj ua teb, oick peptides tuaj yeem pab ua lub zog muaj peev xwm; Piv txwv, PA1B yog cov tshuaj lom tau heev rau grain weevils thiab yoov tshaj cum los ntawm kev haus ncauj. Kev CycloTides thiab lwm yam ick peptides kuj pom cov antimicrobial thiab anticancer ua si, tawm tswv yim zoo li cov neeg sawv cev tshiab.

Tus sawv cev Alick Peptides

PA1B (peas albumin 1 subunit b): 37 {{- Aa peptide nrog peb disulfides (ick quav (ick quav) los ntawm taum taum. Nws yog ib qho kev ua kom muaj kab mob ua kom zoo nkauj, muaj zog tawm tsam cov qoob loo weevils weevils thiab yoov tshaj cum los ntawm txoj hlua khi v-atpase.

Aglycin: Ib qho 37-AA, 6-cys peptide (peb disulfides) los ntawm taum pauv. Kuj tseem hu ua "Leginsulin," aglycin mimics insulin kev ua si. Qhov ncauj aylycin txo qis cov ntshav hauv cov qauv ntshav qab zib los ntawm kev txhim kho insulin signaling, thiab nws tiv taus kev zom zaub mov los ntawm cov plab zom mov thiab cov hnyuv.

Vglycin: Tus ick peptide heev zoo ib yam li aglycin, muab tau los ntawm taum pauv / pea. Nws ua kom pom cov insulin zoo sib xws {{1} Zoo li cov kev cuam tshuam, txhim kho insulin recenor thiab cov glucose kev thev taus.

IGlyCin, DglyCin: Lwm yam PA1B - zoo li peptides los ntawm taum pauv hauv tsev neeg Leginsulin. Lawv kuj qhia insulin -} Cov metabolic me me, tswj cov metabolism thiab tiv thaiv {4 4}} ntawm tes.

-}} astratide am1: ib 6 {{{{{{{} Cys cystine-nplua nuj peptide los ntawm cov tshuaj ntsuabAstragalus Membranaceus, Muaj cov txheej txheem siab ua ntu zus rau PA1B. AM1 yog kab tsuag (cytoToxic rau kab sf9 hlwb) thiab khij txo cov incensicic hauv nas mancreatic- ntawm nws lub luag haujlwm hauv qab zib ingostasis.

Nchuav Disulfide- Daim Ntawv Cog Lus Cyclization Pepties Synthesis Services

Disultfide - rich coltide peptides tau tsim kev txaus siab rau kev kho kom zoo nkauj rau kev siv tshuaj lom neeg, enzymatic, lossis thermal nres. Peb niaj hnub ua ke nrog ib leeg, ob chav thiab ntau ntau tus choj disulfide ntawm peptides nrog cov khoom purity siab heev.

Tiv tauj peb ntawmsales@biorunstar.comTxhawm rau tham txog koj cov kev cai disulfide - daim ntawv cog lus cyclization ntawm peptides synthesis project.

ReFLERENY

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