Kev sib piv ntawm Cov Khoom Siv Tshuaj ntawm PNA thiab DNA
PNA (peptide nucleic acid) thiab DNA (deoxyribonucleic acid) muaj qhov sib txawv tseem ceeb hauv cov khoom siv tshuaj lom neeg, feem ntau tshwm sim hauv lawv cov qauv molecular, cov khoom siv, cov hauv paus, thiab cov qauv spatial.
Cov qauv molecular thiab cov khoom siv
Lub cev pob txha molecular ntawm DNA txuas nrog kev sib hloov deoxyribose thiab phosphate bonds los ntawm phosphodiester bonds. Cov saw tseem ceeb ntawm PNA yog tsim los ntawm kev rov ua dua N - (2-aminoethyl) - glycine units txuas nrog peptide bonds (amide bonds). Qhov no txhais tau hais tias cov saw tseem ceeb ntawm PNA tsis muaj cov pab pawg phosphodiester tsis zoo, uas ua rau kev sib txuas ntawm PNA thiab DNA strands muaj zog dua ntawm DNA strands.
Lub hauv paus muaj pes tsawg leeg
Lub hauv paus ntawm DNA yog adenine (A), thymine (T), cytosine (C), thiab guanine (G). Hauv qhov sib piv, lub hauv paus ntawm PNA fuses nrog N ntawm glycine feem ntawm cov saw tseem ceeb los ntawm cov qauv acetyl. Txawm hais tias PNA lub hauv paus ua ntu zus tuaj yeem khi rau DNA strands, lawv txoj kev sib khi thiab kev ruaj ntseg sib txawv. Lub hauv paus ntawm PNA sab chains tuaj yeem tsim cov ntawv cog lus hydrogen nrog lub hauv paus ntawm ob lub helix lub ntsiab zawj ntawm ob txoj hlua khi RNA lossis DNA, yog li khi rau sab nraud ntawm ob txoj hlua khi RNA lossis DNA.
Spatial qauv thiab muaj nuj nqi
DNA feem ntau muaj nyob rau hauv ob chav helix qauv, uas yog ib qho tseem ceeb rau kev tswj kev ruaj ntseg thiab kis tau tus kab mob cov ntaub ntawv. PNA tuaj yeem tsim cov qauv triple helix, uas muaj qhov tshwj xeeb zoo hauv qee yam kev siv xws li gene editing thiab nucleic acid sensing.
Combining nta thiab kev siv
Vim tias tsis muaj cov pab pawg phosphodiester tsis zoo hauv cov saw tseem ceeb ntawm PNA, nws tuaj yeem khi rau DNA thiab RNA ntawm cov ntsev tsawg. Cov yam ntxwv no ua rau PNA ruaj khov thiab tshwj xeeb thaum siv los ua kev sojntsuam lossis kev xa tshuaj. Lub metabolic stability thiab muaj zog binding affinity ntawm PNA ua rau nws ib tug pab tau lub cuab tam rau kev kho noob caj noob ces, uas yuav inhibit qhov splicing los yog txhais lus ntawm lub hom phiaj mRNA.
Cov ntsiab lus
Zuag qhia tag nrho, qhov sib txawv tseem ceeb hauv cov khoom siv tshuaj lom neeg ntawm PNA thiab DNA nyob hauv lawv cov qauv molecular, cov khoom siv, cov hauv paus, thiab cov qauv spatial. Cov kev sib txawv no muab cov txiaj ntsig zoo rau PNA hauv qee yam kev siv, tshwj xeeb hauv cov teb xws li kev kho cov noob thiab nucleic acid sensing.
