Kev xaiv thiab siv cov kuab tshuaj zoo ib puag ncig
Kev xaiv cov kuab tshuaj muaj qhov cuam tshuam loj rau kev ua haujlwm ntawm peptide synthesis thiab qhov zoo ntawm cov khoom kawg. Ib txwm peptide synthesis feem ntau siv cov kuab tshuaj xws li dimethylformamide (DMF). Txawm hais tias nws muaj zog solubility thiab o muaj peev xwm ntawm peptide resins, nws yog maj mam hloov los ntawm ib puag ncig tus phooj ywg cov kuab tshuaj nyob rau hauv xyoo tas los no vim nws muaj peev xwm toxicity.
Kev xaiv cov kuab tshuaj hloov
2-methyltetrahydrofuran (2-MeTHF): tau siv rau cov khoom sib txuas ntawm Aib enkephalin pentapeptide ntawm polyethylene glycol qaum peptide resin. Cov kab mob sib txuas yog DIC/OxymaPure hauv 2-MeTHF, thiab pawg Fmoc raug tshem tawm nrog 20% piperidine hauv 2-MeTHF.
Gamma valerolactone: tau siv los hloov DMF rau SPPS ntawm Aib ACP decapeptide ntawm ChemMatrix resin. Hauv qhov no, DMF tseem siv rau kev ntxuav thiab Fmoc tshem tawm cov kauj ruam. Cov kws tshawb fawb tau pom tias feem ntau Fmoc amino acid derivatives yog soluble hauv - valerolactone ntawm 0.1M, ua rau cov kuab tshuaj no muaj txiaj ntsig zoo rau kev sib xyaw ua ke.
Propylenecarbonate: tau siv los ua cov kuab tshuaj hloov pauv rau DMF rau peptide synthesis, nrog rau cov khoom sib txuas ntawm cuaj peptide bradykinin ntawm ChemMatrix resin (Fmoc/tBu lub tswv yim).
Daim ntawv thov zoo ntawm ib puag ncig tus phooj ywg cov kuab tshuaj
Kev siv cov kuab tshuaj ib puag ncig tsis yog tsuas yog pab txo cov pa phem ib puag ncig, tab sis kuj tseem txhim kho kev ua haujlwm thiab kev nyab xeeb ntawm peptide synthesis. Piv txwv li, gamma valerolactone, ua lwm txoj hauv kev, txo qhov kev puas tsuaj rau kev noj qab haus huv thaum tswj nws cov nyhuv hluavtaws.
Xaus
Hauv cov ntsiab lus, daim ntawv thov ntawm ib puag ncig tus phooj ywg cov kuab tshuaj nyob rau hauv peptide synthesis tsis tsuas yog qhia txog lub tswv yim ntawm ntsuab chemistry, tab sis kuj muab cov lus qhia tshiab rau kev txhim kho peptide synthesis technology. Nrog rau kev nce qib ntawm kev siv thev naus laus zis thiab kev paub txog kev tiv thaiv ib puag ncig, ntau cov kuab tshuaj zoo ib puag ncig yuav raug tsim thiab siv rau hauv peptide synthesis yav tom ntej, txhawb txoj kev loj hlob ntawm peptide chemistry thiab tshuaj tshawb fawb thiab kev loj hlob.